Critical care admixtures wall chart list of iv drugs. Tigecycline is a firstinclass glycylcycline antibiotic, developed as a third generation structural analog of older tetracyclines. Tygacil 50mg powder for solution for infusion summary of. Tygacil is not indicated for treatment of diabetic foot infection or hospitalacquired pneumonia, including ventilatorassociated pneumonia. Each monograph contains stability data, administration guidelines, and methods of preparation. Trissel, fashp, 2010, american society of healthsystem pharmacists. In an openlabel, ascending multipledose study, 39 children aged 8 to 11 years with ciai or cssti were administered tigecycline 0. Thus, 5 ml of reconstituted solution is equivalent to 50 mg of the drug. The essential information you need to safely administer more than 400 intravenous drugs. It is also active against meticillinresistant staphylococcus aureus and vancomycinresistant enterococci. Find information about common, infrequent and rare side effects of tigecycline intravenous.
Intravenous injection introduced directly into a vein or a freely flowing iv line. Intravenous compatibility chart acyclovir acyclovir. Intravenous admixtures preparation and infusion guidelines. Tigecycline tygacil is an antibiotic used to treat complicated skin infections caused by susceptible strains of bacteria, for treating complicated intraabdominal infections caused by susceptible strains of bacteria, and to treat communityacquired bacterial pneumonia.
Tigecycline is a glycylcycline antibacterial structurally related to the tetracyclines. As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include grampositive and gramnegative organisms, including those of multidrug resistance. Tygacil tigecycline side effects, images, uses, dosage. Healthy subjects received a single 100 mg iv dose of tigecycline followed by 50 mg iv q 12 h. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. Thus, tigecycline may have activity against tetracyclineresistant organisms. Home explore intravenous compatibility chart drug information for the. Tigecycline for severe clostridium difficile infection.
Intravenous compatibility chart drug information for the. Tigecycline belongs to a group of drugs called glycycline antibiotics, which work by binding to bacteria and killing them this medication comes in an injectable form to be given directly into the vein iv by a healthcare provider. Tygacil is a tetracycline class antibacterial indicated in patients 18 years of age and older for. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Although it is structurally related to minocycline, alterations to the molecule resulted in its expanded spectrum of activity and decreased susceptibility to the development of resistance when compared with other tetracycline antibiotics. Tigecycline in saline and the novel formulation were prepared fresh twice a day. This prevents formation of peptide chains in bacteria, thus interfering with their growth. It displays broadspectrum, potent activity against both grampositive and gramnegative bacteria, including many multidrugresistant pathogens. A novel formulation of tigecycline has enhanced stability. It is also active against meticillinresistant staphylococcus aureus and vancomycinresistant enterococci, but pseudomonas aeruginosa and many strains of proteus spp are resistant to tigecycline.
Tigecycline injection may make your skin sensitive to sunlight or ultraviolet light. Tygacil tigecycline dose, indications, adverse effects. Complicated skin and skin structure infections complicated intraabdominal infections communityacquired bacterial pneumonia limitations of use. Tygacil tigecycline is a tetracyclinelike antibiotic used to treat many different bacterial infections of the skin or the digestive system. Reconstituted solution must be transferred and further diluted for iv infusion. Both tigecycline and the novel formulation reduced tumor volume and.
A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. Essential coverage of 48 of the most common and complex iv drugs, including drip rate calculation charts, drug calculation formulae, and much more help you safely and efficiently administer iv drugs. Renal dose adjustment guidelines for antimicrobials crrt. Food and drug administration 10903 new hampshire avenue silver spring, md 20993 1888infofda 18884636332 contact fda. In a pooled analysis of these trials, based on a random effects model by trial weight, an adjusted risk difference of allcause mortality was 0. Tigecycline inhibits protein production in bacteria by binding to the 30s ribosomal subunit and blocking entry of transfer rna molecules into the ribosome of the bacteria. Infuse over 30 to 60 minutes through dedicated line or via ysite. If the same iv line is used for sequential infusion of several drugs, flush line with ns, d5w, or lr before and after tigecycline administration. Tooth discoloration has also occurred in older children and in young adults. In addition to updating drug interactions, precautions, alerts, and patient teaching. Tigecycline is an antibiotic for a number of bacterial infections. Does tigecycline have a place in therapy for hospital.
Tigecycline has a reduced potential for resistance, as it is not affected by the two major mechanisms of tetracycline resistance. Full text monographs for most every injectable drug available are reported in the complete king guide to parenteral admixtures. Intravenous iv preparation and infusion guidelines globalrph. Potassium chloride, propofol, ropivacaine, tigecycline, ziconotide, and zidovudine.
The tigecycline regimen was noninferior to the imipenemcilastatin group for nonvap, but did not meet the. Administer iv infusions over about 30 to 60 minutes. Store in the iv bag at room temperature for up to 6 h, or refrigerated at 2. However, because of its extensive distribution into tissue, high blood levels are not maintained, so tigecycline is probably not a good choice for patients with bacteremia. Intravenous compatibility chart free html5 flip book. If the same iv line is used for sequential infusion of several drugs, flush the line before and after infusion of this drug with an infusion solution compatible to all drugs. If the same iv line is used for sequential infusion of several different drugs, the line should be flushed before and after infusion of tigecycline with an infusion solution compatible with tigecycline and with any other drugs administered via this common line, such as 0. For the treatment of complicated intraabdominal infections due to susceptible isolates of citrobacter freundii, enterobacter cloacae, escherichia coli, klebsiella oxytoca, k pneumoniae. Side effects of tygacil tigecycline, warnings, uses. Each vial of tygacil should be reconstituted with 5.
Tigecycline has a large volume of distribution 12 lkg, penetrating well into bone, lung, liver, and kidney tissues. It was developed in response to the growing rate of antibiotic resistant bacteria such as staphylococcus aureus, acinetobacter baumannii, and e. The cause of this increase has not been established. Intermittent an infusion from a burette or minibag running over approximately 1560 minutes. Results the use of iv andor ivt tigecycline was described in 39 patients infected with healthcareassociated a. All patients received iv tigecycline for a minimum of 3 consecutive days to a maximum of 14 consecutive days, with the option to be switched to an oral antibiotic on or after day 4.
Tigecycline shows higher binding affinity than tetracyclines, being active against bacterial strains with either mechanism of tetracycline resistance efflux and ribosomal protection. Common and rare side effects for tigecycline intravenous. Additive compatibility drugs in syringe compatibility. Tigecycline is a glycylcycline antibiotic derived from the tetracycline group, that acts by inhibiting protein synthesis at the level of the bacterial ribosome. Digital books looseleaf edition database licensing.
The recommended dose of tigecycline is 100 mg iv bolus followed by 50 mg iv every 12 hours to be delivered over 30 to 60 minutes. But you must use the medicine within 24 hours up to 6 hours in the vial and the other 18 hours in the iv bag. Mixed medicine in an iv bag may be kept at cool room temperature. Tigecycline is the first drug in the glycylcycline class of antibiotics. Tigecycline is currently approved in north america for the treatment of adults with complicated skin. Continuous an infusion running over more than 1 hour.
Fully updated coverage includes the newest iv treatments with magnesium, conivaptan, potassium, and nicardipine, helping you provide the most. The following is the list of drugs found on the king guide to parenteral admixtures critical care admixtures wall chart. Tigecycline is a prescription medication used to treat serious skin and stomach infections and certain types of pneumonia lung infection. Children younger than 8 years may be more sensitive to the side effects of tigecycline, especially tooth discoloration. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Tigecycline is active against grampositive and gramnegative bacteria, including tetracyclineresistant organisms, and some anaerobes. In addition to updating drug interactions, precautions, alerts, and patient teaching instructions for all existing iv drugs, this new 36th edition includes over a dozen new monographs of the most recent iv drugs. Usual duration of therapy is 5 14 days, although actual duration should be dictated by the site and severity of infection and the patients overall clinical status. Incompatibilities are based on meeting any of the following criteria.
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